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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD4
All Species:
17.58
Human Site:
T259
Identified Species:
32.22
UniProt:
Q13485
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13485
NP_005350.1
552
60439
T259
G
F
T
G
Q
P
A
T
Y
H
H
N
S
T
T
Chimpanzee
Pan troglodytes
XP_001155006
493
53820
Q249
S
G
P
Q
P
G
Q
Q
Q
N
G
F
T
G
Q
Rhesus Macaque
Macaca mulatta
XP_001095978
493
53880
Q249
S
G
P
Q
P
G
Q
Q
Q
N
G
F
T
G
Q
Dog
Lupus familis
XP_849370
552
60457
T259
G
F
T
A
Q
P
A
T
Y
H
H
N
S
T
T
Cat
Felis silvestris
Mouse
Mus musculus
P97471
551
60399
T258
G
F
T
A
Q
P
S
T
Y
H
H
N
S
T
T
Rat
Rattus norvegicus
O70437
552
60451
T259
G
F
T
A
Q
P
A
T
Y
H
H
N
S
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509486
552
60450
T259
G
F
A
A
Q
P
A
T
Y
H
H
N
S
T
T
Chicken
Gallus gallus
P84023
426
48233
P182
N
Y
I
P
E
T
P
P
P
G
Y
L
S
E
D
Frog
Xenopus laevis
NP_001090536
549
59837
A256
N
G
F
S
A
Q
P
A
T
Y
H
H
N
S
T
Zebra Danio
Brachydanio rerio
Q9I8V2
472
53048
T228
S
P
F
Q
M
P
E
T
P
P
P
A
Y
M
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
N211
S
S
V
N
S
N
P
N
S
P
Y
D
S
L
A
Honey Bee
Apis mellifera
XP_392838
578
62051
H283
N
S
P
V
S
P
V
H
L
H
H
S
N
G
F
Nematode Worm
Caenorhab. elegans
P45897
570
63351
Y264
I
C
I
N
P
Y
H
Y
E
R
V
V
S
N
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.6
88
98.9
N.A.
98
98.7
N.A.
97.4
37.8
90.9
35.5
N.A.
36.9
66
26.4
N.A.
Protein Similarity:
100
88.7
88.9
99.2
N.A.
98.7
98.9
N.A.
98.5
51.4
94.3
50
N.A.
51
74
41.4
N.A.
P-Site Identity:
100
0
0
93.3
N.A.
86.6
93.3
N.A.
86.6
6.6
13.3
13.3
N.A.
6.6
20
6.6
N.A.
P-Site Similarity:
100
13.3
13.3
93.3
N.A.
93.3
93.3
N.A.
86.6
26.6
40
13.3
N.A.
20
33.3
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
31
8
0
31
8
0
0
0
8
0
0
8
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% D
% Glu:
0
0
0
0
8
0
8
0
8
0
0
0
0
8
0
% E
% Phe:
0
39
16
0
0
0
0
0
0
0
0
16
0
0
8
% F
% Gly:
39
24
0
8
0
16
0
0
0
8
16
0
0
24
0
% G
% His:
0
0
0
0
0
0
8
8
0
47
54
8
0
0
0
% H
% Ile:
8
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
8
0
0
8
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
24
0
0
16
0
8
0
8
0
16
0
39
16
8
0
% N
% Pro:
0
8
24
8
24
54
24
8
16
16
8
0
0
0
8
% P
% Gln:
0
0
0
24
39
8
16
16
16
0
0
0
0
0
16
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
31
16
0
8
16
0
8
0
8
0
0
8
62
8
0
% S
% Thr:
0
0
31
0
0
8
0
47
8
0
0
0
16
39
47
% T
% Val:
0
0
8
8
0
0
8
0
0
0
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
0
8
39
8
16
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _